Severe combined immunodeficiency disorders (SCID) is the term used to cover the most serious types of primary immunodeficiency. In all forms of SCID both T and B lymphocyte functions, the body’s defence mechanisms, are defective from birth.
Affected infants are highly susceptible to severe, persistent and unusual infections, and survival beyond the first year of life is highly unlikely without diagnosis and treatment of their condition, which is usually through a bone marrow or stem cell transplant to boost the immune system. Prior to the transplant, affected children with a combination of immunodeficiency disorders need to be cared for in a sterile environment.
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